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BMR: Dynamic Protein Interactions
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Updated: 07.12.2009 
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Research focus: Protein interactions regulating the microtubule cytoskeleton Recently, we have witnessed the massive growth of research on protein interactions and networks. Obtaining mechanistic insights into their structural components and modes of regulation is necessary to understand how these often dynamic and transient interactions translate into cellular functions. We use X-ray crystallography in combination with biochemical and biophysical methods to investigate protein complexes implicated in the regulation of the microtubule filament system. Our research portfolio also includes protein interactions involved in coiled coil and amyloid formation. For more information on our activities, please consult our research projects, selected research achievements or publications sites. An important tool to raise the efficiency of multiple target cloning and expression is a robotics based screening technology platform. The pipeline scheme “from gene to crystal structure” is complemented by crystallization robotics and an automated diffraction screening beamline at PSI's Swiss Light Source (SLS). Our Group is part of the laboratory of Biomolecular Research in the Biology and Chemistry Department at the Paul Scherrer Institut (PSI) and is associated to the Department of Biology of ETH Zürich.
Location: We are located at the Paul Scherrer Institut in CH-5232 Villigen, Switzerland, about 35 km north-west of Zürich and 55 km east of Basel. You can reach us either by public transport or by car.
Contact Address: Michel O. Steinmetz Phone: +41-56-310-4754 Secretary:
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